Lyme disease is often underestimated. It usually starts with a small tick bite, some fever, maybe a rash — and if caught early, it can be cured with antibiotics. But what if it’s missed? What if the symptoms are mistaken for something else? That’s when advanced Lyme disease quietly creeps in, affecting the body in more complex and painful ways. This article will guide you through everything you need to know about advanced Lyme disease symptoms in humans — from the causes and risk factors to the signs you shouldn’t ignore, and the treatments that offer hope.